IRRICAD™ — Available as a standalone program and now as a plug-in for AutoCAD® and BricsCAD. Go to IRRICAD LINK for details about the new plug in.

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The study aimed to develop pre-clinical diagnosis of Alzheimer's disease (AD) and - in future - preventive therapy in patients with mild cognitive impairment (MCI). The MCI group (n=44) and AD group (n=42, including 18 patients with soft dementia and 24 patients with mild dementia) were studied. The groups were matched for age (median 70 and 69 years for MCI and AD groups, respectively).

The control group comprised 24 mentally healthy relatives of the patients. Correlations between the activity/amounts of platelet enzymes: cytochrome c-oxidase (COX), glutamine synthetase-like protein (GSLP) and the extent of cognitive impairment were studied. The COX activity in MCI and AD groups was significantly lower than in the control group (Kruskal-Wallis test p=0.0001, χ²=11.6, p=0.003). These tests showed significant differences in GSLP amount between three groups (p=0.04 and χ²=9.38, p=0.01, respectively). Significant reverse correlation (Spearman R= -0.43, p=0.007) was found between GSLP amount and MMSE scores for MCI+AD group, i.e., the lower MMSE scores, the higher platelet GSLP level.

Platelet COX and GSLP may be considered as early markers of cognitive impairment.

Irrigation Design Software IrriCAD Pro is an advanced computer-aided design (CAD) software for designing and optimizing pressurized irrigation systems. Far more than just a drawing package, it combines the advantages of CAD drawing with powerful hydraulic pipe sizing, automatic pipe fittings selection and optimized network analysis. Based on the data and its calculations, the system generates a detailed graphical representation of the irrigation system layout and a comprehensive bill of materials. User-Friendly Design Interface The software features a user friendly and intuitive design environment which streamlines the work of the irrigation designer.

It offers easy entry of site information and system component data, while automatically converting drawing items into hydraulic components. The interface offers the ability to create irrigation areas by easily inputting subdivisions of large blocks. Its quick labeling feature and automatic legend generation, dramatically reduces design efforts and costs. Automatic Pipe Sizing and Hydraulic Analysis IrriCAD Pro offers automated pipe sizing and hydraulic analysis utilizing comprehensive interpolation between contours and spot heights for determining pressures and calculating true pipe lengths. In addition, IrriCAD Pro calculates the system duty of each system flow (station), allowing seamless selection of the optimal pump for operating the system. Automatic Cost Calculations and Detailed BOM Selecting the appropriate system components is considered to be one of the most time-consuming tasks for the designer.

IrriCAD Pro automates this tedious process by featuring automated selection of fittings from its comprehensive database. Netafim supplies IrriCAD Pro with a comprehensive database containing fittings, pipe, sprinkler and other components from various manufacturers. Based on the selection, IrriCAD automatically generates a comprehensive Bill of Materials and provides detailed design and costing reports.